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Name
ID

Lat
linker for activation of T cells
MGI:1342293

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Defective T cell proliferation

Decreased circulating IgA level

Decreased circulating antibody level

Coombs-positive hemolytic anemia

Abnormal B cell count

Decreased proportion of CD4-positive T cells

Increased proportion of gamma-delta T cells

T lymphocytopenia

Lymphopenia

Abnormal natural killer cell count

Autoimmune thrombocytopenia

Splenomegaly

Disease(s) Associated with LAT

immunodeficiency 52

Mouse Phenotypes

abnormal T cell proliferation

increased T cell proliferation

abnormal thymus cell ratio

small thymus

thymus hypoplasia

decreased thymocyte number

abnormal thymocyte activation

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal lymphopoiesis

abnormal B cell differentiation

abnormal T cell differentiation

abnormal T cell selection

decreased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

abnormal gamma-delta T cell differentiation

arrested T cell differentiation

increased susceptibility to autoimmune hemolytic anemia

increased eosinophil cell number

abnormal B cell number

increased plasma cell number

increased B cell number

abnormal T cell subpopulation ratio

increased T-helper 2 cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

absent mature gamma-delta T cells

increased gamma-delta T cell number

increased mature gamma-delta T cell number

increased memory T cell number

decreased regulatory T cell number

decreased T cell number

absent T cells

increased T cell number

abnormal lymphocyte morphology

abnormal plasma cell morphology

abnormal T cell morphology

abnormal T-helper 2 cell morphology

abnormal effector T cell morphology

abnormal mature gamma-delta T cell morphology

abnormal spleen morphology

abnormal spleen white pulp morphology

increased spleen germinal center number

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal splenic cell ratio

abnormal B cell activation

increased IgE level

increased IgG1 level

increased IgM level

increased immunoglobulin level

abnormal T cell physiology

abnormal T-helper 2 physiology

abnormal T cell activation

abnormal platelet aggregation

decreased platelet aggregation

Availability

Mouse Genotype

Lat^tm1.1Mal/Lat^tm1.1Mal

Lat^tm1Bpay/Lat^tm1Bpay

Lat^tm1Les/Lat^tm1Les

Lat^tm2.1Lov/Lat^tm2.1Lov

Lat^tm2.1Mal/Lat^tm2.1Mal

Lat^tm3.1Mal/Lat^tm3.1Mal

Lat^tm4.1Mal/Lat^tm4.1Mal

Lat^tm5.1Mal/Lat^tm5.1Mal

Lat^tm9Mal/Lat^tm9Mal

Lat^tm1Les/Lat^tm1.1Wz

Lat^tm1Les/Lat^tm1.2Wz

Lat^tm1Les/Lat^tm1.1Wz
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23